Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer.

Guan Y, Yang YJ, Nagarajan P, Ge Y. Exp Dermatol. 2021 Apr;30(4):529-545. doi: 10.1111/exd.14247. 

NFI Transcription Factors Provide Chromatin Access to Maintain Stem Cell Identity While Preventing Unintended Lineage Fate Choices.

Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. Nat Cell Biol 2020 Jun;22(6):640-650.

Extracellular serine controls epidermal stem cell fate and tumor initiation.

Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, NovakJSS, Tierney MT, Racelis J, Fuchs E and Finley LWS. Nat Cell Biol 2020 Jul;22(7):779-790.

The aging skin microenvironment dictates stem cell behavior.

Ge Y, Miao Y, Gur-Cohen S, Nikolova M, Gomez NC, Yang H, Polak L, Krueger JG, Hu Y, Verma A, Elemento O and Fuchs E. Proc Natl Acad Sci U S A 2020; 117, 5339-5350

Distinct modes of cell competition shape mammalian tissue morphogenesis.

Ellis S, Gomez NC, Levorse J, Mertz AF, Ge Y, Fuchs E. Nature 2019; 569(7757):497-502 Learn more

Unraveling cancer lineage drivers in squamous cell carcinomas.

Guan Y, Wang G, Fails D, Nagarajan P, Ge Y. Pharmacol Ther. 2019 Dec 11:107448 Learn more

Stretching the Limits: From Homeostasis to Stem Cell Plasticity in Wound Healing and Cancer

Ge Y, Fuchs E. Nature Reviews Genetics 2018; 19(5):311-325 Learn more

Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression

Adam RC, Yang H, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh S, Zheng D, Fuchs E. Cell Stem Cell 2018; 22(3):398-413.e7 Learn more

Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.

Ge Y, Gomez NC, Adam RC, Nikolova M, Yang H, Verma A, Lu CP, Polak L, Yuan S, Elemento O, Fuchs E. Cell 2017; 169(4):636-650. [Leading edge preview in Cell http://dx.doi.org/10.1016/j.cell.2017.04.030] Learn more

Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices.

Yang H, Adam RC, Ge Y, Hua ZL, Fuchs E. Cell 2017; 169(3):483-496. Learn more