Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging.

Lyu Y, Ge Y. Front Cell Dev Biol. 2022 May 19;10:903904. Learn more

KLF5 governs sphingolipid metabolism and barrier function of the skin.

Lyu Y, Guan Y, Deliu L, Humphrey E, Frontera JK, Yang YJ, Zamler D, Kim KH, Mohanty V, Jin K, Mohanty V, Liu V, Dou J, Veillon LJ, Kumar SV, Lorenzi PL, Chen Y, McAndrews KM, Grivennikov S, Song X, Zhang J, Xi Y, Wang J, Chen K, Nagarajan P, Ge Y. Genes Dev. 2022 Aug 25;36(13-14):822-42. Learn more

αSMA+ myofibroblasts orchestrate skin wound repair via b1 integrin and independent of type I collagen production

McAndrews KM, Miyake T, Ehsanipour EA, Kelly PJ, Becker LM, McGrail DJ, Sugimoto H, LeBleu VS, Ge Y, Kalluri R. EMBO J. EMBO J. 2022 Apr 4;41(7):e109470. Learn more

Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer.

Guan Y, Yang YJ, Nagarajan P, Ge Y. Exp Dermatol. 2021 Apr;30(4):529-545. doi: 10.1111/exd.14247. 
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NFI Transcription Factors Provide Chromatin Access to Maintain Stem Cell Identity While Preventing Unintended Lineage Fate Choices.

Adam RC, Yang H, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. Nat Cell Biol 2020 Jun;22(6):640-650. Learn more

Extracellular serine controls epidermal stem cell fate and tumor initiation.

Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, NovakJSS, Tierney MT, Racelis J, Fuchs E and Finley LWS. Nat Cell Biol 2020 Jul;22(7):779-790. Learn more

The aging skin microenvironment dictates stem cell behavior.

Ge Y, Miao Y, Gur-Cohen S, Nikolova M, Gomez NC, Yang H, Polak L, Krueger JG, Hu Y, Verma A, Elemento O and Fuchs E. Proc Natl Acad Sci U S A 2020; 117, 5339-5350 Learn more

Distinct modes of cell competition shape mammalian tissue morphogenesis.

Ellis S, Gomez NC, Levorse J, Mertz AF, Ge Y, Fuchs E. Nature 2019; 569(7757):497-502 Learn more

Unraveling cancer lineage drivers in squamous cell carcinomas.

Guan Y, Wang G, Fails D, Nagarajan P, Ge Y. Pharmacol Ther. 2019 Dec 11:107448 Learn more

Stretching the Limits: From Homeostasis to Stem Cell Plasticity in Wound Healing and Cancer

Ge Y, Fuchs E. Nature Reviews Genetics 2018; 19(5):311-325 Learn more